A Study of Different Sequences of Cilta-cel, Talquetamab in Combination With Daratumumab and Teclistamab in Combination With Daratumumab Following Induction With Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in Participants With Standard-risk Newly Diagnosed Multiple Myeloma
The purpose of this study is to evaluate the rate of response (how effectively treatment
is working) with signs of potential cure at 5 years after the start of induction
treatment. This is defined as a composite of sustained (at least 2 years) minimal
residual disease (MRD) negativity with complete response/stringent complete response
(CR/sCR) and a positron emission tomography/computed tomography (PET/CT) scan that does
not show any signs of cancer at 5 years. MRD negativity and CR/sCR is defined as no
detectable signs of remaining cancer cells after the treatment. This study will also
characterize how well the treatments administered work in the study through
progression-free survival (PFS). PFS is defined as the length of time during and after
the treatment of a disease, that a participant lives with the disease, but it does not
get worse.